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Research

Nutritional modification of gut in vitro with lysophosphatidic supplements

Abstract

Cell culture offers a number of advantages including fast-track biological questions to improve our understanding of finer details of the cellular and molecular interactions. This welfare-friendly 3R compatible research project investigates the effect of commercial lysophospholipids on membrane integrity and nutrition assimilation of fish gut cells.

Description

Major components of cell membrane bi-layer are phospholipids. Due to their key functionalities in the cellular membrane, Lysophospholipids (LPLs) have been extensively studied and scientifically proven to affect nutrient absorption through various methods, including partial changes to the membrane structure, stimulation of protein channels, and modulation of membrane fluidity. LPL has registered in the category of feed additive and is widely used in the animal feed industry.

The defined benefit of the commercial LPLs includes enhancing nutrient absorption, thereby enhancing animal performance. Also, the synergic effects of LPLs and enzyme products can provide additional cost savings in feed formulation through complete digestion, reducing food waste as excretion from the animal body. It also, minimises the nutrient and energy loss from the feed, hence enabling an eco-friendly and sustainable production in the farm and feed business.

Cell culture offers a number of advantages including fast-track biological questions to improve our understanding of finer details of the cellular and molecular interactions. This welfare-friendly 3R compatible project investigates the effect of commercial LPLs on membrane integrity and nutrient assimilation in rainbow trout gut cell line (RTGutGC).

Funding Body

EASY BIO, Inc. 4th floor, 310, Gangnam-daero, Gangnam-gu, Seoul, 06253, South Korea

Lead Organisation

Harper Adams University

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